Radiesse
The Dual-action Collagen Biostimulator
Radiesse® is an advanced dermal filler and biostimulator composed of calcium hydroxylapatite (CaHA) microspheres. First FDA-approved in 2006, it is uniquely designed to provide immediate volumisation while simultaneously stimulating your body’s natural collagen and elastin production for gradual, long-lasting rejuvenation.
With:
- Over 15 years of clinical use globally
- FDA and CE certifications
- Millions of treatments performed worldwide
Radiesse has built a robust safety profile and is recognised as one of the most versatile structural and regenerative injectables in aesthetic medicine.
What Is Radiesse?
Radiesse is a dual-action injectable treatment that goes beyond simply filling lines.
When injected into the dermis or subcutaneous layer, it provides an immediate lifting and firming effect due to its aqueous gel carrier. Over time, the microscopic Calcium Hydroxylapatite (CaHA) particles initiate a controlled regenerative response. This stimulates fibroblasts to produce new, healthy collagen and elastin, restoring lost volume and improving skin quality progressively.
Depending on your needs, Radiesse can be used in two ways:
- Undiluted: To restore deep facial volume, contour the jawline, and lift severe folds (like nasolabial and marionette lines).
- Hyperdiluted: When thinned with saline and lidocaine, it acts purely as a skin bio-stimulator. It improves skin quality, firmness, and tightness on the face, neck, décolletage, and hands without adding extra bulk.
How Does Radiesse Work?
Unlike traditional hyaluronic acid (HA) fillers that solely occupy space and draw in water, Radiesse physically rebuilds the skin’s structural foundation.
As we age, the collagen and elastin that keep our skin firm and tight begin to deplete, leading to sagging and wrinkles. Radiesse directly addresses this depletion. Upon injection, the CaHA microspheres form a physical “scaffold” under the skin. This framework supports and maintains the skin’s inner structure while signalling your body’s natural healing response to generate new, youth-restoring proteins.
ADVANCED CaHA TECHNOLOGY
The formulation of Radiesse features smooth, synthetic Calcium Hydroxylapatite (CaHA) particles suspended in a water-based gel carrier. CaHA is a biocompatible substance identical to minerals found naturally in human bones and teeth, meaning no allergy testing is required.
As the body gradually absorbs the gel carrier over the first few weeks, the CaHA microspheres remain to trigger natural regeneration (neocollagenesis and neoelastinogenesis) with minimal inflammatory response.
Eventually, the CaHA particles are safely metabolised into calcium and phosphate ions and naturally excreted, leaving behind only your body’s newly produced collagen.
Mechanism Of Action
Once injected, Radiesse works through mechanotransduction:
- Immediate Lift: The high-viscosity gel immediately fills and lifts the targeted area.
- Cellular Activation: CaHA microspheres stimulate fibroblast activity.
- Regeneration: Promotes the deposition of Type I and Type III collagen, alongside elastin.
- Angiogenesis: Encourages new blood vessel growth, supporting healthier, glowing skin.
Clinical studies show:
- Active collagen and elastin production peaks between 4 to 9 months following injection.
- Dermal thickness and skin elasticity significantly improve.
- Results typically last 12 to 18 months, making it one of the longest-lasting non-permanent injectables available.
Who Is Suitable For Radiesse?
Radiesse is highly versatile and ideal for individuals who:
- Require immediate structural support and lifting (e.g., jawline contouring or cheek augmentation).
- Have deep wrinkles or folds, such as nasolabial folds or marionette lines.
- Want to rejuvenate thin, crepey skin on the neck, décolletage, or hands (using hyperdiluted Radiesse).
- Are experiencing age-related volume loss and collagen depletion.
- Prefer a filler that provides structural tightening without a “puffy” or overfilled appearance (as it does not draw water like HA fillers).
Why Choose EC Clinic London?
- Personalised Treatment Planning
Using advanced D9 skin imaging analysis, we assess your skin’s structural integrity, volume distribution, and collagen density to design a bespoke Radiesse strategy tailored to your exact anatomy.
- Precision Layered Injection Techniques
Our experts utilise anatomically guided techniques, seamlessly switching between undiluted Radiesse for deep structural support and hyperdiluted Radiesse for superficial skin tightening.
- Advanced Reconstitution Protocol
For hyperdiluted treatments, we utilise rigorous mixing protocols to ensure a smooth, uniform dispersion of CaHA particles, maximising neocollagenesis while virtually eliminating the risk of nodules.
- Structured Follow-Up System
Post-treatment monitoring includes repeat imaging analysis to assess your collagen regeneration and refine any future aesthetic planning.
Frequently Asked Questions
You will notice immediate volumisation and lifting right after the procedure. As the gel carrier is absorbed, your body’s natural collagen takes over, with peak skin quality improvements appearing over the next 2 to 4 months.
Unlike some biostimulators that require a strict multi-session course, Radiesse often achieves desired results in a single session, though a touch-up may be recommended after a few months depending on your goals.
Yes. Radiesse has an excellent global safety record, is FDA-approved, and relies on calcium hydroxylapatite, a material with a long history of safe use in medicine.
Unlike hyaluronic acid fillers, Radiesse cannot be dissolved with an enzyme like hyaluronidase. It is safely and naturally metabolised by the body over time. This highlights the importance of choosing highly experienced practitioners like our team at EC Clinic London.
This is a specialised technique where Radiesse is thinned out with a mixture of saline and lidocaine. Instead of adding volume to the face, it is spread superficially under the skin to act purely as a bio-stimulator, smoothing and tightening areas like the neck, chest, and hands.
Related Treatments
Profhilo®
An injectable skin booster with the highest concentration of hyaluronic acid to deeply hydrate and remodel the skin.
Dermal Fillers
Hyaluronic acid-based gels designed to hydrate, contour, and instantly fill specific folds and lines.
Sculptra
The original PLLA collagen regenerator for gradual, global facial volumisation.
