Plinest & Newest Polynucleotides
The Next Generation Of Biostimulation
Created by Mastelli, an Italian pharmaceutical pioneer with over 70 years of research, Plinest and Newest represent the forefront of regenerative aesthetic medicine. Using highly purified polynucleotides (PN-HPT®), these treatments do not just mask the signs of ageing; they repair and regenerate your skin cells from within.
With proven clinical safety and efficacy, Mastelli’s polynucleotide injectables offer natural rejuvenation, improved elasticity, and deep hydration without altering your natural facial contours.
What Are Polynucleotides?
Polynucleotides are the building blocks of DNA. In aesthetic medicine, highly purified DNA fragments (typically sourced from trout) are used as regenerative signalling molecules.
Once injected into the skin, these biocompatible fragments act like messengers. They stimulate your body’s fibroblast cells to naturally ramp up the production of collagen, elastin, and hyaluronic acid. Unlike traditional dermal fillers that simply occupy space to add volume, polynucleotides actively repair tissue damage at a cellular level, reducing inflammation and improving overall skin health, texture, and resilience.
What Is Plinest?
The Pure Skin Regenerator
Plinest is a pure polynucleotide injectable designed to fundamentally improve skin quality, structure, and firmness. Formulated with Mastelli’s patented PN-HPT® (High Purification Technology), Plinest triggers a powerful regenerative response without adding any artificial volume.
Key Benefits of Plinest:
- Under-Eye Rejuvenation: Exceptionally effective for the delicate periocular area. It tightens crepey skin and reduces dark circles without the “puffiness” sometimes associated with tear-trough fillers.
- Total Skin Quality: Smooths uneven texture, reduces acne scarring, and diminishes fine lines across the face, neck, and décolletage.
- Cellular Repair: Scavenges free radicals and reduces skin inflammation, actively slowing down the aging process.
What Is Newest?
The Hydrating Biostimulator
While Plinest focuses purely on regeneration, Newest offers a powerful dual-action formula. It combines Mastelli’s signature PN-HPT® polynucleotides with Hyaluronic Acid (HA).
This synergistic blend means that while the polynucleotides work long-term to stimulate collagen and repair tissue, the hyaluronic acid provides an immediate surge of deep hydration and a subtle, radiant plumpness to the skin.
Key Benefits of Newest:
- Dual-Action Repair: Merges long-term cellular regeneration with immediate moisture retention.
- Revives Dehydrated Skin: Ideal for dry, dull, or sun-damaged skin that has lost its natural luminosity.
- Restores Bounce: Specifically targets areas suffering from a loss of elasticity, providing a structural lift and deep tissue hydration simultaneously.
Advanced Pn-hpt® Technology
Both Plinest and Newest utilise Mastelli’s proprietary High Purification Technology (PN-HPT®). This multi-step extraction and purification process ensures:
- The removal of all residual proteins, guaranteeing exceptionally high purity and safety.
- Complete biocompatibility with human tissue, minimising the risk of allergic reactions.
- The creation of long-chain polynucleotides that maximise fibroblast stimulation and tissue repair.
Which Treatment Is Right For You?
Because both treatments work at the cellular level, your EC Clinic London practitioner will select the exact formulation based on your skin’s unique needs:
Choose Plinest if you want to:
- Target delicate areas like under-eye dark circles and crepey eyelids.
- Improve skin density, firmness, and elasticity.
- Address acne scarring, rosacea, or overall skin texture without adding volume.
- Focus on preventative anti-aging.
Choose Newest if you want to:
- Rescue severely dehydrated, dry, or sun-damaged skin.
- Achieve an immediate hydrated “glow” while waiting for long-term collagen production.
- Treat deeper fine lines and visible signs of aging on the face, neck, or hands.
Why Choose EC Clinic London?
- Personalised Treatment Planning
Using advanced skin imaging, we assess your skin’s hydration levels, collagen depletion, and tissue quality before deciding whether Plinest, Newest, or a combination of both is right for your unique anatomy.
- Precision Injection Techniques
Our expert practitioners use advanced needle and cannula techniques to deposit the polynucleotides exactly where your cells need them most, ensuring maximum fibroblast activation with minimal downtime.
- Synergistic Combination Therapies
We understand that regenerative medicine works best comprehensively. We can safely integrate Plinest and Newest into a wider treatment plan, combining them with energy-based devices (like Morpheus8 or Thermage FLX) for unparalleled results.
- Structured Follow-Up System
True regeneration takes time. We monitor your collagen production and skin quality improvements over your treatment course, dynamically refining your protocol for lasting radiance.
Frequently Asked Questions
With Newest, you will notice an immediate improvement in hydration and glow thanks to the Hyaluronic Acid. For the regenerative effects of Plinest and Newest, optimal results typically peak at 2–3 months as your body naturally produces new collagen and elastin.
A standard course consists of 2 to 4 sessions, spaced 3 to 4 weeks apart. Maintenance sessions are recommended every 6 months to sustain skin quality.
Yes. Both products are manufactured by Mastelli, which has over 70 years of experience. The PN-HPT® purification process ensures a highly biocompatible product with an excellent safety profile. (Note: As they are derived from fish DNA, they are not suitable for those with fish allergies).
No. Neither Plinest nor Newest acts as a traditional volumising filler. They are biostimulators that repair the skin’s framework. They will not alter your facial shape or restrict muscle movement.
Related Treatments
Profhilo®
The ultimate hyaluronic acid bio-remodelling treatment for skin laxity.
Polynucleotides (Ameela/Rejuran)
DNA-based injectables for cellular regeneration and repairing dark circles.
PicoWay Laser
Advanced laser technology for shattering deeper pigmentation and melasma.
